Beychac et Caillau, the 10th of June 2020

A unique research program dedicated to preventing cognitive decline in the elderly

Activ’Inside, an SME specialized in developing and producing active plant ingredients for the Health Nutrition industries, announces the launch of the Silver Brain Food project. This program is carried out in collaboration with the University Laboratories of NutriNeuro and Bordeaux Population Health, as well as a consortium of industrial companies. Silver Brain Food aims at developing local, personalized solutions, products and services to promote a nutrient-rich diet, essential for brain health, to the elderly, and therefore prevent cognitive decline This research program has a total budget of €16.3 million, including €9.3 million from the Investments for the Future Program (PIA) operated by Bpifrance.

Responding to a major public health issue

While age related cognitive decline is a normal part of the aging process, it can lead to a higher cognitive impairment or disease such as dementia, its main form being Alzheimer’s (around 70% of cases of dementia). This disease currently has no cure and frequently requires treatment by specialized facilities, representingan estimated cost of 23 billion euros per year in France. Activ’Inside started the Silver Brain Food project to respond to this major economic and public health issue.

Prevent cognitive decline through a high neuro-nutritional density diet

Silver Brain Food is a research project that aims at preventing cognitive decline of elderly people thanks to a diet rich in nutrients for brain health. Drawing on the technical, scientific and industrial expertise of the 5 members of the consortium, Silver Brain Food plans to:

• Develop extracts rich in neuro phytonutrients obtained through an innovative industrial eco-process.
• Develop a range of high-density neuro-nutritional foods standardized in nutrients scientifically validated for their preventive actions against cognitive decline.
• Develop digital nutritional coaching solutions and personalized non-stigmatizing follow-up services for individuals and professional caretakers to promote high neuro-nutritional density diet .

On top of these groundbreaking innovations, the project plans to create a network of neighborhood shops offering products and services to promote elderly people’s well-being at home.

A project built on promising results

The launch of the Silver Brain Food project is a continuation of the research work initiated by Activ’Inside:

• A first study based on epidemiological data conducted by the U1219 Bordeaux Population Health research center (Joint Research Unit (UMR) INSERM-University of Bordeaux) and Activ’Inside demonstrated that people who consume high quantities of a combination of polyphenols, including grapes, had a 50% reduction of the incidence of dementia and Alzheimer’s disease!
• Furthermore, a consortium of industrial and academic partners led by Activ’Inside and the NutriNeuro laboratory (UMR INRAE​​/University of Bordeaux/INP) launched a research project. Conducted between 2011 and 2018, this project highlighted the clinical effectiveness of Memophenol ^TM, a formulation of polyphenols from grapes and blueberries developed by Activ’Inside, on the normal cognitive decline of elderly people. These results were also deemed promising by a leading international medical journal (JAMA) and a first health claim on Memophenol ^TM which was delivered by health authorities in South Korea in late 2019.

Based on these promising first results, members of Silver Brain Food are now planning to obtain new claims on cognitive decline prevention within 5 years.

Academic and industrial partners – the guarantee of scientific objectification

This project is certified by the Agri Sud-Ouest Innovation, Vitagora and Systematic competitiveness clusters and is supported by the Silver Valley cluster. It calls on the synergy of skills from both industrial and academic partners to ensure scientific objectification.

The project’s industrial partners:

• The SME Activ’Inside (project leader) which specializes in developing, producing and marketing active plant ingredients (from grapes and saffron) for the Health Nutrition industries, especially the field of neuro nutrition
• EC6 is an expert in catering and hospital and geriatric nutrition
• GoodMix is an expert in digital nutritional coaching solutions 

In addition to these partners, there is a user committee which will bring together companies likely to test the solutions that will be developed during the project. The first industrial ETI in the food industry has already joined this committee.

The project’s academic partners are:

• The NutriNeuro Joint Research Unit (UMR) (National Institute for Agronomic Research and the Environment INRAE, University of Bordeaux and Bordeaux INP) which specializes in integrated nutrition and neurobiology
• The Joint Research Unit (UMR) U1219 “Bordeaux Population Health” (National Institute of Health and Medical Research INSERM-University of Bordeaux) which specializes in epidemiology of nutrition and aging

More about ACTIV’INSIDE

Based in Bordeaux area, Activ’Inside is an independent foodtech company specialized in the development, production and marketing of natural active ingredients (mainly from grape and saffron) for the Health Nutrition Industries. 

BORDEAUX (France), October 27, 2019 – Memophenol™, the clinically-proven innovative patented solution to prevent the age-related cognitive decline on seniors, is confirmed to act as a memory booster by the Journal of the American Medical Association (JAMA).

Since its launch in 2017, Memophenol™ gains credibility on the scientific community. The JAMA, a peer-reviewed international medical journal with a high scientific level (Impact Factor: 51), published this October 24, 2019 a new article about Polyphenol-rich Grape and Blueberry Extract (PEGB) marketed with the brand Memophenol™. Through a precise description of the clinical protocol and results, this unique and synergistic blend of French grape and wild blueberry extracts is described as a promising memory booster to prevent the age-related cognitive decline.

Click here to access the JAMA publication

This article quotes a randomized, bicentric, double-blind placebo-controlled clinical study including 215 healthy seniors, from 60 to 70 years old supplemented with 600mg of Memophenol™ (or placebo) during 6 months, conducted by Activ’Inside and its partners. Compared to the baseline and the placebo group, Memophenol™ supplementation significantly improves short-term memory and reverts cognitive age by up to 1 decade.

Click here to access Memophenol™ clinical study

Memophenol™ is based on an international research program and is now supported by 7 proprietary publications.

For more on Memophenol™: www.memophenol.com

More on ACTIV’INSIDE

Activ’Inside, a French company specialized in saffron (Crocus sativus L.) and grapes (Vitis vinifera L.), aims to develop innovative natural products with high added value. “We use science, analysis, claims, intellectual property and marketing to create unique products reflecting customers’ need for a fast and safe access to market” says Benoit LEMAIRE, CEO of ACTIV’INSIDE.

At Activ’Inside, innovation and science are at the core of our activity, as demonstrated by our 3 patented active solutions based on sound scientific knowledge, proprietary published studies and related claims: MemophenolTM, for cognitive health, SkinAxTM, for the skin beauty, Safr’insideTM, for mood / quality of sleep / premenstrual comfort.

Active solutions’s website : http://skinax.comI http://memophenol.comI http://safrinside.com

Activ’Inside has developed a unique organic OPC grape seed extract with the highest amount of Oligomer Proanthocyanidins (OPC) with the most accurate method: >25% by Porter. This extract is a treasure from French grapes and it is also available in 100% organic version. The softest & the most traditional extraction process is used to preserve all the proprieties of the grape. This grape seed extract has powerful multi-tasking benefits like anti-ageing and hypocholesterolemia proprieties and is backed by pending EFSA claims.

More on ACTIV’INSIDE

Activ’Inside, a French company specialized in saffron (Crocus sativus L.) and grapes (Vitis vinifera L.), aims to develop innovative natural products with high added value. “We use science, analysis, claims, intellectual property and marketing to create unique products reflecting customers’ need for a fast and safe access to market” says Benoit LEMAIRE, CEO of ACTIV’INSIDE.

At Activ’Inside, innovation and science are at the core of our activity, as demonstrated by our 3 patented active solutions based on sound scientific knowledge, proprietary published studies and related claims: MemophenolTM, for cognitive health, SkinAxTM, for the skin beauty, Safr’insideTM, for mood / quality of sleep / premenstrual comfort.

Active solutions’s website : http://skinax.comI http://memophenol.comI http://safrinside.com

At Beychac et Caillau, the 30th of August 2019

Beychac & Caillau (France), August 28, 2019 – Memophenol^TM, the clinically-proven innovative patented solution to prevent the age-related cognitive decline on seniors, is confirmed to act as a booster of cognitive performance. Its effectiveness in acute dosage has been evaluated on students by Activ’Inside in a new clinical study.

Nowadays, 20% of students use “smart nootropic drugs” as cognitive boosters to stay competitive and focused. These nootropics, mainly Modafinil or Methylphenidate used in pharmaceutical drugs, have potential long-term side effects [Nature journal, 2008]. To offer quick benefits comparable to those of nootropic drugs without their side effects, Activ’Inside proposes its 100% natural & patented formula Memophenol™ to boost students’ cognitive performance in acute dosage.

Activ’Inside conducted a randomized, double-blind placebo-controlled crossover clinical study including 30 French graduated students, from 18 to 25 years old. The crossover approach makes the comparison more powerful as students are their own control.  Each student took both placebo & 600mg of Memophenol^TMin acute dosage, 90 minutes before a one-hour intense mental effort. Cognitive performance, including working memory, attention & alertness, was assessed by both objective and self-assessment validated tests in exam conditions.

In 90 minutes only, Memophenol^TMacute supplementation induces booster effects. Objective results show that Memophenol™ significantly maintains higher cognitive performance by 36% when students were supplemented with Memophenol™ compared to the placebo. This gold-standard clinical study not only proved Memophenol™ effectiveness, it also convinced students by its benefits on cognitive performance: students under Memophenol™ supplementation felt significantly more performant by 39%, according to self-assessment results. These clinical results are subject to a new proprietary patent highlighting Memophenol™ quick effectiveness in acute dosage.

For more on Memophenol^TM: www.memophenol.com

More on ACTIV’INSIDE

Activ’Inside, a French company specialized in saffron (Crocus sativus L.) and grapes (Vitis vinifera L.), aims to develop innovative natural products with high added value. “We use science, analysis, claims, intellectual property and marketing to create unique products reflecting customers’ need for a fast and safe access to market” says Benoit LEMAIRE, CEO of ACTIV’INSIDE.

At Activ’Inside, innovation and science are at the core of our activity, as demonstrated by our 3 patented active solutions based on sound scientific knowledge, proprietary published studies and related claims: MemophenolTM, for cognitive health, SkinAxTM, for the skin beauty, Safr’insideTM, for mood / quality of sleep / premenstrual comfort.

Active solutions’s website : http://skinax.comI http://memophenol.comI http://safrinside.com

At Beychac et Caillau, the 24th of July 2019

Activ’Inside announces Memophenol™ selection as ingredient of the year for Healthy aging category at the NutraIngredients Awards Asia 2019.

Memophenol™ did it again! Over the past 4 years, this is the 3^rdselection at a prestigious award for the Activ’Inside star ingredient. Launched in 2016, Memophenol™ has already been awarded twice in Europe. First named as the laureate for “pharmaceutical product” category at Vitafoods 2016, Geneva, Memophenol™ won its second European award at Vitafoods 2017, Geneva, as the ingredient of the year in “Healthy Aging” category.

The second step was to be recognized around the world in the name of all the scientists involved in this long-lasting international consortium led by Activ’Inside. The company took up this challenge successfully in Asia this year. Selected in the same category “Healthy aging”, Memophenol™ is the fruit of 4 years of research, 7 proprietary publications, 2 clinical studies, and 2 international patents. This 100% natural ingredient is a promising way to improve memory and cognitive performance, on young actives and old people.

Bordering on faultless, Memophenol™ is competing as finalist for the Ingredient of the year – Healthy Aging, to be bestowed in Asia on September, 24^th2019. Activ’Inside will be present at Vitafoods Asia in Singapore, 25-26 September on booth E2.

Active solutions’s website : http://skinax.comI http://memophenol.comI http://safrinside.com