Memophenol™: The Journal of the American Medical Association highlights the “anti-aging” effect of grape and blueberry polyphenols on elderly memory

Memophenol™: The Journal of the American Medical Association highlights the “anti-aging” effect of grape and blueberry polyphenols on elderly memory

BORDEAUX (France), October 27, 2019 – Memophenol™, the clinically-proven innovative patented solution to prevent the age-related cognitive decline on seniors, is confirmed to act as a memory booster by the Journal of the American Medical Association (JAMA).

Since its launch in 2017, Memophenol™ gains credibility on the scientific community. The JAMA, a peer-reviewed international medical journal with a high scientific level (Impact Factor: 51), published this October 24, 2019 a new article about Polyphenol-rich Grape and Blueberry Extract (PEGB) marketed with the brand Memophenol™. Through a precise description of the clinical protocol and results, this unique and synergistic blend of French grape and wild blueberry extracts is described as a promising memory booster to prevent the age-related cognitive decline.

Click here to access the JAMA publication

This article quotes a randomized, bicentric, double-blind placebo-controlled clinical study including 215 healthy seniors, from 60 to 70 years old supplemented with 600mg of Memophenol™ (or placebo) during 6 months, conducted by Activ’Inside and its partners. Compared to the baseline and the placebo group, Memophenol™ supplementation significantly improves short-term memory and reverts cognitive age by up to 1 decade.

Click here to access Memophenol™ clinical study

Memophenol™ is based on an international research program and is now supported by 7 proprietary publications.

For more on Memophenol™: www.memophenol.com

More on ACTIV’INSIDE

Activ’Inside, a French company specialized in saffron (Crocus sativus L.) and grapes (Vitis vinifera L.), aims to develop innovative natural products with high added value. “We use science, analysis, claims, intellectual property and marketing to create unique products reflecting customers’ need for a fast and safe access to market” says Benoit LEMAIRE, CEO of ACTIV’INSIDE.

At Activ’Inside, innovation and science are at the core of our activity, as demonstrated by our 3 patented active solutions based on sound scientific knowledge, proprietary published studies and related claims: MemophenolTM, for cognitive health, SkinAxTM, for the skin beauty, Safr’insideTM, for mood / quality of sleep / premenstrual comfort.

Active solutions’s website : http://skinax.comI http://memophenol.comI http://safrinside.com

A unique OPC organic grape seed extract

A unique OPC organic grape seed extract

Activ’Inside recently launches an organic grape seed extract guaranteed with the highest level in OPC,Grape’InsideTM 60P CO, part of the Signature grapeTM range.

 

Activ’Inside has developed a unique organic OPC grape seed extract with the highest amount of Oligomer Proanthocyanidins (OPC) with the most accurate method: >25% by Porter. This extract is a treasure from French grapes and it is also available in 100% organic version. The softest & the most traditional extraction process is used to preserve all the proprieties of the grape. This grape seed extract has powerful multi-tasking benefits like anti-ageing and hypocholesterolemia proprieties and is backed by pending EFSA claims.

“Through our expertise in sourcing, extraction processes, and analysis, we’ve been able to develop such extract and guarantee the highest organic OPC amount on the market”, said Benoit Lemaire, CEO and Business and marketing VP of Activ’Inside.

 

For more on OPC

 

Proanthocyanidins (PACS) are the major phenolic compounds in grape seeds. They generally occur as oligomers and polymers of a basic monomeric unit of flavanols (catechin, epicatechin). Oligomers of proanthocyanidins, known as OPC, are composed by a minimum of 2 monomer units, until a maximum of 10 units.

OPC are potent antioxidants as scientific publications report their capacity to promote secondary antioxidant activity and inhibit oxidative processes. This is why the organic grape seed extract has a high ORAC value: 7500 μmol Trolox/g.

OPC also provide significant hypocholesterolemia effects and are largely associated with the “French paradox”.

 

For more on Porter

Activ’Inside guarantees the OPC levels of its grape seed extracts by the Porter method. While convenient UV methods and vanillin assay overestimate the OPC amount by interacting with other polyphenols, the Porter method is more precise and allows characterizing “real OPC”. All the OPC Signature grapeTM seedextracts offered by Activ’Inside are guaranteed with the Porter method for optimal anti-aging and cardiovascular benefits.

 

 

More on ACTIV’INSIDE

Activ’Inside, a French company specialized in saffron (Crocus sativus L.) and grapes (Vitis vinifera L.), aims to develop innovative natural products with high added value. “We use science, analysis, claims, intellectual property and marketing to create unique products reflecting customers’ need for a fast and safe access to market” says Benoit LEMAIRE, CEO of ACTIV’INSIDE.

At Activ’Inside, innovation and science are at the core of our activity, as demonstrated by our 3 patented active solutions based on sound scientific knowledge, proprietary published studies and related claims: MemophenolTM, for cognitive health, SkinAxTM, for the skin beauty, Safr’insideTM, for mood / quality of sleep / premenstrual comfort.

Active solutions’s website : http://skinax.comI http://memophenol.comI http://safrinside.com

 

 

 

Memophenol™: clinical study in acute dosage

Memophenol™: clinical study in acute dosage

At Beychac et Caillau, the 30th of August 2019

Beychac & Caillau (France), August 28, 2019 – MemophenolTM, the clinically-proven innovative patented solution to prevent the age-related cognitive decline on seniors, is confirmed to act as a booster of cognitive performance. Its effectiveness in acute dosage has been evaluated on students by Activ’Inside in a new clinical study.

 

 

Nowadays, 20% of students use “smart nootropic drugs” as cognitive boosters to stay competitive and focused. These nootropics, mainly Modafinil or Methylphenidate used in pharmaceutical drugs, have potential long-term side effects [Nature journal, 2008]. To offer quick benefits comparable to those of nootropic drugs without their side effects, Activ’Inside proposes its 100% natural & patented formula Memophenol™ to boost students’ cognitive performance in acute dosage.

 

Activ’Inside conducted a randomized, double-blind placebo-controlled crossover clinical study including 30 French graduated students, from 18 to 25 years old. The crossover approach makes the comparison more powerful as students are their own control.  Each student took both placebo & 600mg of MemophenolTMin acute dosage, 90 minutes before a one-hour intense mental effort. Cognitive performance, including working memory, attention & alertness, was assessed by both objective and self-assessment validated tests in exam conditions.

 

In 90 minutes only, MemophenolTMacute supplementation induces booster effects. Objective results show that Memophenol™ significantly maintains higher cognitive performance by 36% when students were supplemented with Memophenol™ compared to the placebo. This gold-standard clinical study not only proved Memophenol™ effectiveness, it also convinced students by its benefits on cognitive performance: students under Memophenol™ supplementation felt significantly more performant by 39%, according to self-assessment results. These clinical results are subject to a new proprietary patent highlighting Memophenol™ quick effectiveness in acute dosage.

 

 

For more on MemophenolTM: www.memophenol.com

 

 

 

More on ACTIV’INSIDE

Activ’Inside, a French company specialized in saffron (Crocus sativus L.) and grapes (Vitis vinifera L.), aims to develop innovative natural products with high added value. “We use science, analysis, claims, intellectual property and marketing to create unique products reflecting customers’ need for a fast and safe access to market” says Benoit LEMAIRE, CEO of ACTIV’INSIDE.

At Activ’Inside, innovation and science are at the core of our activity, as demonstrated by our 3 patented active solutions based on sound scientific knowledge, proprietary published studies and related claims: MemophenolTM, for cognitive health, SkinAxTM, for the skin beauty, Safr’insideTM, for mood / quality of sleep / premenstrual comfort.

Active solutions’s website : http://skinax.comI http://memophenol.comI http://safrinside.com

 

 

 

Memophenol™ finalist at NutraIngredients Awards Asia 2019

Memophenol™ finalist at NutraIngredients Awards Asia 2019

At Beychac et Caillau, the 24th of July 2019

Activ’Inside announces Memophenol™ selection as ingredient of the year for Healthy aging category at the NutraIngredients Awards Asia 2019.

 

Memophenol™ did it again! Over the past 4 years, this is the 3rdselection at a prestigious award for the Activ’Inside star ingredient. Launched in 2016, Memophenol™ has already been awarded twice in Europe. First named as the laureate for “pharmaceutical product” category at Vitafoods 2016, Geneva, Memophenol™ won its second European award at Vitafoods 2017, Geneva, as the ingredient of the year in “Healthy Aging” category.

The second step was to be recognized around the world in the name of all the scientists involved in this long-lasting international consortium led by Activ’Inside. The company took up this challenge successfully in Asia this year. Selected in the same category “Healthy aging”, Memophenol™ is the fruit of 4 years of research, 7 proprietary publications, 2 clinical studies, and 2 international patents. This 100% natural ingredient is a promising way to improve memory and cognitive performance, on young actives and old people.

Bordering on faultless, Memophenol™ is competing as finalist for the Ingredient of the year – Healthy Aging, to be bestowed in Asia on September, 24th2019. Activ’Inside will be present at Vitafoods Asia in Singapore, 25-26 September on booth E2.

 

Active solutions’s website : http://skinax.comI http://memophenol.comI http://safrinside.com

 

 

 

Safr’Inside™: the only encapsulated saffron extract

Safr’Inside™: the only encapsulated saffron extract

At Beychac et Caillau, the 28th of may 2019

Activ’Inside introduced Safr’insideTM, the first encapsulated saffron extract at Vitafoods Europe 2019 in Geneva. Manufactured in France through patented extractionTM process Tech’care that confers a natural encapsulation of saffron volatile and sensitive metabolites, Safr’InsideTM provides an optimized safranal concentration: up to 10 times more than other saffron extracts. 

 

 

saffron Flower encapsulation

So far, saffron extracts used to nutraceutical applications are not sufficiently characterized, and render only part of the active metabolites originally present in Iranian saffron stigmas. This is mainly due to the applied extraction processes that alter most of saffron active metabolites. Such as safranal and crocin, which are highly volatile and/or thermosensitive compounds. To preserve their richness of the raw material (Iranian saffron stigmas), Activ’Inside has developed and patented a soft-extraction process: Tech’care extraction™. Made in France, this process is based on an innovative extraction/absorption combination: during their extraction, saffron metabolites are preserved from heat and solvent alterations thanks to the addition of a carrier. This unique process provides a natural encapsulation of saffron metabolites.

 

 

 


Saffron particles trapped in the maltodextrin support.                                      Saffron particles and support are separated

Preserves and optimizes safranal concentration                                               No protection of saffron volatile metabolites

 

Compared to a classic atomization process in which saffron particles and support are separated, the Tech’care extractionTM process allows saffron particles to be surrounded by the carrier matrix. Such process protects saffron volatile metabolites, especially safranal, and optimizes its concentration in the final extract. According to U-HPLC analysis, Safr’Inside™ is significantly richer in safranal than other saffron extracts: up to 10 times more than Spanish saffron extract.

 

     More on ACTIV’INSIDE

 

Activ’Inside, a French company specialized in saffron (Crocus sativus L.) and grapes (Vitis vinifera L.), aims to develop innovative natural products with high added value. “We use science, analysis, claims, intellectual property and marketing to create unique products reflecting customers’ need for a fast and safe access to market” says Benoit LEMAIRE, CEO of ACTIV’INSIDE.

 

At Activ’Inside, innovation and science are at the core of our activity, as demonstrated by our 3 patented active solutions based on sound scientific knowledge, proprietary published studies and related claims: MemophenolTM, for cognitive health, SkinAxTM, for the skin beauty, Safr’insideTM, for mood / quality of sleep / premenstrual comfort.

 

Active solutions’s website : http://skinax.comI http://memophenol.comI http://safrinside.com