Sponsor of the skipper Gildas BRETON for the 11e edition of “La Route du Rhum”

Beychac & Caillau, 2^nd October 2018: A sail, a boat and the ocean as far as the eye can see. This is what awaits the skipper Gildas Breton from November the 4^th when he will start the most difficult competition of his career: La Route du Rhum.

He won’t be alone in this great adventure. It’s notably in the colors of ACTIV’INSIDE that Gildas will take the race in Saint Malo, in Brittany, direction Point-à-Pitre, in Guadeloupe. How many participants this year? No fewer than 124 boats, a record, including 21 opponents Gildas will have to face in the RhumMulti category.

We’re counting on you Gildas! Follow us on twitter and Linkedin to keep informed on Gildas progress during the race.

More on Gildas Breton?

Aged of 55, Gildas is a real sea lover. Rocked by sailing since childhood, his record is growing year after year. Last reward: 2^nd place in real time at the Tour de Groix in 2017. For him, « La route du rhum » is a totally new challenge: “It’s a race that any sailor wants to do one day. This experience of crossing the Atlantic in solo is a real challenge, especially in terms of sleep, for me who have, so far, always took part of regatta between three buoys “says Gildas Breton to “La route du rhum” organizers (http://urlz.fr/7Rh8).

The skipper brilliantly completed the qualifications and is now in the phase of physical, mental and boat technical preparation. In order to protect his skin which will be under severe stress during its journey due to UV, wind, iodine and sea salt, Gildas Breton will take the active ingredient SkinAx^2TM, an antioxidant new-generation developed by Activ’Inside. SkinAx^2TM is a unique strong formula with a dual mechanism of action, combining both primary and secondary antioxidants, especially from grape monomers.

For more about Gildas Breton: www.forceocean.fr

More on “La route du Rhum” 

The “Route du Rhum” is a legendary French race taking place every 4 years. It will celebrate this year its 40 years. For this occasion, a beautiful gift: not less than 124 registered boats compared to only 38 the first year in 1978, and only 91 at the last edition in 2014. On the program, impressive numbers: about 6,560 km to go, 11 different nationalities, 124 boats of distinctive sizes divided into 6 categories, a starting line of more than 5 Km, for a solo crossing race of more than one week. The record is held by Loick Peyron, winner of the race in 2014, in 7 days, 15h, 8 minutes and 32 seconds.

More about « La route du rhum »: www.routedurhum.com

More on ACTIV’INSIDE: Maker of difference for the nutraceutical market

“What if your products contain more than just ingredients? A lot of science, a dose of analytical characterization, a measure of innovation, all with a quality, intellectual property and marketing coating, you let it go?”

Expert in saffron (crocus sativus L.) and grape (vitis vinifera L.) raw materials, the French biotech aims to develop innovative natural products with strong added values. “We use science, analytical, regulation, intellectual property and marketing to give UNIQUE PRODUCT, reflecting customer needs for a fast and safe access to market”.

ACTIV’INSIDE proposes ingredients for the nutraceutical market, from natural extract – mainly grape, saffron but also other – to patented active solution supported by a strong scientific background, proprietary published studies and relevant claims. 3 actives solutions dedicated to 3 majors application are available today: Cognition, Mood and Skin beauty. ACTIV’INSIDE private labelling with its ingredients.

ACTIV’INSIDE, Science Inside, Claims Outside.

For more information: www.memophenol.com | www.skinAx.com | www.safrinside.com

From Botanical EXTRACTS…

Through our expertise in grape and saffron, we propose ranges of botanical extracts.
We also develop tailor-made extracts according to your specifications.

• Signature saffron™ :

Range of extracts from Sargol saffron stigmas with the richest content in active metabolites including safranal, crocin and safromotivines.

• Signature grape™ :

Range of extracts from several grape parts providing different polyphenol profiles guaranteed according to both UV and U-HPLC analytical methods.

• Signature extract^TM :

Range of natural botanical extracts with guaranteed specifications, with the highest requirement in terms of quality and regulation.

… to dedicated APPLICATIONS

We aim to provide unique products with clear and differentiating messages.

Each are supported by:

• Proprietary studies: In-vitro, in-vivo, pilot, clinical and epidemiological
• Intellectual protection: Patents and trademarks
• Scientific publications: About proprietary studies, mechanisms or analysis methods
• Full analytical characterization: Both quantitative and qualitative
• Identifies mechanism of action: From proprietary and published data
• Relevant claims: EFSA claims, beauty claims and proprietary data

Discover our 3 innovative actives solutions

• : Cognitive Health. memophenol.com
• : Beauty from within. skinax.com
• : Mood, Pre-menstrual comfort, Sleep quality. safrinside.com

Activ’Inside also proposes private labeling with our active solutions, for a quicker and safer access to market.

Lear more about us: visit our dedicated websites including our totally new Memophenol^TM one. And follow us on Twitter and Linkedin.

ACTIV’INSIDE, Science Inside, Claims Outside.

For more information: www.memophenol.com | www.skinAx.com | www.safrinside.com

Finalist as “Botanical Product of the year”
of the Nutra Ingredients Awards Asia 2018

BORDEAUX (France), July 31^st, 2018 – ACTIV’INSIDE has been selected as finalist of the NutraIngredients Awards Asia 2018 with Safr’Inside^TM microtab, as the “Botanical product of the year”.

This original product assures quicker mood benefits, felt within 20 minutes only.

This award is associated with Vitafoods Asia 2018, which will take place at Singapore from 11 to 12 September 2018. ACTIV’INSIDE will be exhibitor at this show, booth N10 with is Asian Distributor Aqurate. Come to see us to discover our products.

Mood benefits felt within 20 minutes only.

Safr’Inside^TM microtab is a prototype of dietary supplement developed by Activ’Inside, in its private labelling offer.       This innovative product provides quick and effective effect on mood, in 20 minutes only, thanks to a sublingual administration and the highest content in safranal.

Contrary to classic dosage forms, Safr’Inside^TM microtab is presented in an original microtablet form. The sublingual administration of the microtablets induces a direct and quicker diffusion of saffron metabolites, including safranal, into the blood circulation, reaching rapidly the brain to positively act on mood regulators and neurotransmitters.

Each stick of 400 mg contains 30 mg of Safr’Inside^TM, the optimal dose demonstrated to have beneficial effect on mood. Safr’inside^TM is a patented extract of Iranian saffron stigmas whose chemical profile is backed by 10 clinical studies published on its mood benefits. Obtained from the reddest part of saffron stigmas (Sargol quality), Safr’Inside^TM provides the richest concentrations in safranal, crocin and safromotivines.

Safr’Inside^TM microtab is dedicated to people subjected to mood swings, afflicting more than 150 million people around the world (Qureshi et al. 2013). About 27% of Europeans, 47% of Americans, and 41% of Asians currently experience affective disorders, that can include nervousness, stress and anxiety. Safr’Inside^TM microtab has been developed to match with these consumer needs, as it represents an efficient science-backed natural mood stabilizer that provides quick benefits.

How does the awards selection works?

Safr’Inside^TM microtab has been selected from several others products. Each participant has submitted a file by May 2018.

“This award celebrates the best branded or own-label supplements, functional foods and beverages containing botanical and TCM (Traditional Chinese Medicine) ingredients”.

The selection was made according to 7 criteria:

• Brand recognition and the commercial success of your product, including evidence of strong retail and consumer interest or listings of your product.
• Consumer demand and interest in your format, delivery system, and/or matrix – including how innovative any delivery system is.
• Whether your product meets a consumer demand, and how relevant the botanical/TCM ingredient is in meeting this demand
• Packaging ease of use and design, including appeal and ease of use, novelty
• Evidence that the product works for its specified use, where possible this will be product specific research, however research citing the main active ingredients solely will also be considered.
• Evidence of that your product and its delivery system(s) has no, or beneficial, impact on bioavailability (especially if citing single ingredient data).
• What gives your product the ‘X factor’ – something that makes it stand out from the crowd and edge out the competition (including evidence to back up claims)

Once all entries had been received, they were reviewed by the NutraIngredients-ASIA Awards Judging Panel made up of independent judges from the industry.

The winner of the NutraIngredients Awards will be announced during awards ceremony on September 10^th, 2018 in Singapore.

More on ACTIV’INSIDE, your expert in Grape and Saffron applications

“What if your products contain more than just ingredients? A lot of science, a dose of analytical characterization, a measure of innovation, all with a quality, intellectual property and marketing coating, you let it go?”

Expert in saffron (crocus sativus L.) and grape (vitis vinifera L.) raw materials, the French biotech company ACTIV’INSIDE knows their compositions and applications more than anyone else. ACTIV’INSIDE proposes a large range of signature saffron and grape extracts, premium quality, including organic, vegan, kosher and halal ones. The company also valorises saffron and grape health benefits by developing proprietary natural active solutions, based on strong scientific background and clinically proven efficacy. 3 actives solutions dedicated to 3 majors application are available: Cognition, Mood and Skin beauty. Furthermore, if you want to be helped in the development of your finished products, ACTIV’INSIDE also proposes private labelling with its ingredients.

“ACTIV’INSIDE is your key partner in all your development projects. We use science, analytical, regulation, intellectual property and marketing to give you a UNIQUE PRODUCT, reflecting your customer needs for a fast and safe access to market” says Benoit LEMAIRE, CEO of ACTIV’INSIDE.

ACTIV’INSIDE, Science Inside, Claims Outside.

For more information: www.memophenol.com | www.skinAx.com | www.safrinside.com

A bi-centric, randomized, double-blind placebo-controlled clinical study confirms Memophenol™ effectiveness on seniors’ memory!

BORDEAUX (France), July 26, 2018 – ACTIV’INSIDE publishes a new study on Memophenol^TM, in the Journal of Gerontology. The clinical study performed on the product shows that the association of specific polyphenols from grape and blueberry improves episodic memory in healthy elderly.

Memophenol^TM clinical study

This study aimed to evaluate the effect of a 6-months dietary supplementation with a Polyphenols-Rich Extract from Grape and Blueberry (PEGB, trademark Memophenol^TM by Activ’Inside) on memory of healthy elderly subjects. The study involved 215 healthy seniors (Mini Mental State Examination score (MMSE) between 26 to 29) aged between 60-70 years old, orally supplemented with 300 mg twice a day of Memophenol^TM.

Learning, short and long-term memories were assessed using validated Neuropsychological tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Two tests were used before (T0) and after 6 months (T6) of supplementation:

• Verbal Recall Memory (VRM) test, assessing short-term memory: 18 words are shown one by one on a screen. People are then asked to recall as many words as possible, immediately (e. 1 min) following the presentation.
• The Paired Associated Learning (PAL) test, assessing long-term episodic memory. During this test, an increasing number of patterns have to be replaced, depending on the levels.

Figure 1: PAL score at baseline of the study population. N=190. Per protocol population.

The population was split into quartiles according to their corresponding baseline scores. Such approach allows selecting subjects according to their basal cognitive decline level.

To evaluate how Memophenol™ could correct a more pronounced memory loss, its effectiveness was evaluated on subjects with the worst PAL score at baseline (decliners) (figure 1).

– Memophenol^TM improves long-term episodic memory and learning

Figure 2: MemophenolTM efficacy on VRM-FR test.

After 6 months of supplementation, in the total population, the study shows that subjects supplemented with Memophenol^TM significantly improves their Verbal Free Recall Recognition Memory (VRM-FR, p=0.006) scores (figure 2).

Figure 3: Memophenol™ efficacy on PAL test assessed on decliners.

In addition, the subjects having the most important cognitive decline at baseline (t=0), also called “decliners”, significantly reduce the number of errors on the PAL test (p=0.037), thus highlighting episodic memory improvements.  This decrease is associated to 24% less errors versus placebo (figure 3).

Finally, the new publication shows that these cognitive improvements are interestingly associated with higher urinary concentration specific flavan-3-ols metabolites in the Memophenol^TM group, confirming that Memophenol^TM supplementation improves memory on seniors with a high bioavailability.

Memophenol^TM demonstrated efficacy

Thanks to this new study, Activ’Inside confirms the effectiveness of Memophenol™ on the age-related cognitive decline.

“This publication is a new piece of the Memophenol^TM puzzle. Indeed, fruit of a 4 year-international research program, Memophenol^TM is supported by not less than 10 publications and 1 patent.” says Benoit LEMAIRE, Chief Executive Officer at Activ’Inside.

Recently, ACTIV’INSIDE also published a new 12-year follow-up epidemiological study conducted with Inserm and Harvard, showing that polyphenols intake can prevent cognitive decline.

– What is Memophenol^TM?

Memophenol^TM is ACTIV’INSIDE innovative active formulation supported by science. Memophenol^TM results from a 4-year international research program initiated and led by ACTIV’INSIDE. This program of 4.2 million euros involved 10 academics and industrial partners, as well as 22 scientists, Ph. D. and engineers well recognized for their expertise in the fields of chemistry and biology of polyphenols, neuroscience and engineering of nutritional active ingredients.

The project started with data from epidemiological studies: polyphenols and specifically flavonoids are preventive effects on cognitive decline. Since that, several in-vitro and in-vivo tests has been performed on besides the large-scale clinical study. The mechanism of action has been identified: Memophenol^TM improves neurogenesis and synaptic plasticity, thanks to its unique profile in bioavailable polyphenols.

The effectiveness of Memophenol^TM has also been approved by students.

For more on Memophenol^TM: www.memophenol.com

More on ACTIV’INSIDE, your expert in Grape and Saffron applications

“What if your products contain more than just ingredients? A lot of science, a dose of analytical characterization, a measure of innovation, all with a quality, intellectual property and marketing coating, you let it go?”

Expert in saffron (crocus sativus L.) and grape (vitis vinifera L.) raw materials, the French biotech company ACTIV’INSIDE knows their compositions and applications more than anyone else. ACTIV’INSIDE proposes a large range of signature saffron and grape extracts, premium quality, including organic, vegan, kosher and halal ones. The company also valorises saffron and grape health benefits by developing proprietary natural active solutions, based on strong scientific background and clinically proven efficacy. 3 actives solutions dedicated to 3 majors application are available: Cognition, Mood and Skin beauty. Furthermore, if you want to be helped in the development of your finished products, ACTIV’INSIDE also proposes private labelling with its ingredients.

“ACTIV’INSIDE is your key partner in all your development projects. We use science, analytical, regulation, intellectual property and marketing to give you a UNIQUE PRODUCT, reflecting your customer needs for a fast and safe access to market” says Benoit LEMAIRE, CEO of ACTIV’INSIDE.

ACTIV’INSIDE, Science Inside, Claims Outside.

Polyphenols intake can prevent cognitive decline

Conducted by Inserm, Activ’Inside and Harvard, a 12-year follow-up epidemiological study was performed on 1329 healthy French people aged 65 years old and above to investigate how a diet rich in polyphenols could prevent cognitive decline.Activ’Inside has just published an in-house U-HPLC method for saffron characterization in the journal Food chemistry. 

This study shows that a higher polyphenols consumption reduces by 50% the risk of having a severe cognitive decline*.

These results confirm the important role of polyphenols in MemophenolTM. This patented innovative active solution is a specific association of polyphenols-rich extracts from French grape and wild blueberry, clinically proven to enhance learning, short-term and long-term memories, and to prevent cognitive decline.

More on  www.memophenol.com

* According to the study «Lefevre-Arbogast et al. 2018, Neurology, Pattern of polyphenol intake and the long-term risk of dementia in older persons», when comparing the population in the highest quartile of polyphenols intake with the lowest quartile.

Study conducted by:

• INSERM : Institut National de la Santé Et de la Recherche Médicale (National Institute of Health and Medical Research).
• ACTIV’INSIDE : We use science, analytical methods, regulation, intellectual property and marketing to give you UNIQUE PRODUCTS, reflecting customer needs for a fast and safe access to market.
• HARVARD : Private Research University of Public Health.

ACTIV’INSIDE, Science Inside, Claims Outside.

For more information: www.memophenol.com | www.skinAx.com | www.safrinside.com

for saffron characterization

Activ’Inside has just published an in-house U-HPLC method for saffron characterization in the journal Food chemistry.

Quality assessment of saffron (Crocus sativus L.) extracts via UHPLC-DAD-MS analysis and detection of adulteration using gardenia fruit extract (Gardenia jasminoides Ellis). Moras et al. 2018

This new method :

• Identifies more than 25 active metabolites in saffron

Recent publications shown that the saffron effectiveness is not conveyed by safranal and crocins only, but also by the synergistic action of numerous secondary compounds that include picrocrocins, crocetins, flavonoids, and their derivatives.

• Guarantees high safranal concentration (0.2% U-HPLC)

The conventional UV method (ISO 3632) method commonly used to determine the quality of saffron is not specific enough and overestimates the safranal content.

• Guarantees the absence of adulterations

Especially coming from other species (Gardenia Jasminoides Ellis.)

More on ACTIV’INSIDE, your expert in Grape and Saffron applications

“What if your products contain more than just ingredients? A lot of science, a dose of analytical characterization, a measure of innovation, all with a quality, intellectual property and marketing coating, you let it go?”

Expert in saffron (crocus sativus L.) and grape (vitis vinifera L.) raw materials, the French biotech company ACTIV’INSIDE knows their compositions and applications more than anyone else. ACTIV’INSIDE proposes a large range of signature saffron and grape extracts, premium quality, including organic, vegan, kosher and halal ones. The company also valorises saffron and grape health benefits by developing proprietary natural active solutions, based on strong scientific background and clinically proven efficacy. 3 actives solutions dedicated to 3 majors application are available: Cognition, Mood and Skin beauty. Furthermore, if you want to be helped in the development of your finished products, ACTIV’INSIDE also proposes private labelling with its ingredients.

“ACTIV’INSIDE is your key partner in all your development projects. We use science, analytical, regulation, intellectual property and marketing to give you a UNIQUE PRODUCT, reflecting your customer needs for a fast and safe access to market” says Benoit LEMAIRE, CEO of ACTIV’INSIDE.

ACTIV’INSIDE, Science Inside, Claims Outside.

For more information: www.memophenol.com | www.skinAx.com | www.safrinside.com