At Beychac et Caillau, the 28th of may 2019

Activ’Inside introduced Safr’inside^TM, the first encapsulated saffron extract at Vitafoods Europe 2019 in Geneva. Manufactured in France through patented extraction^TM process Tech’care that confers a natural encapsulation of saffron volatile and sensitive metabolites, Safr’Inside^TM provides an optimized safranal concentration: up to 10 times more than other saffron extracts. 

So far, saffron extracts used to nutraceutical applications are not sufficiently characterized, and render only part of the active metabolites originally present in Iranian saffron stigmas. This is mainly due to the applied extraction processes that alter most of saffron active metabolites. Such as safranal and crocin, which are highly volatile and/or thermosensitive compounds. To preserve their richness of the raw material (Iranian saffron stigmas), Activ’Inside has developed and patented a soft-extraction process: Tech’care extraction™. Made in France, this process is based on an innovative extraction/absorption combination: during their extraction, saffron metabolites are preserved from heat and solvent alterations thanks to the addition of a carrier. This unique process provides a natural encapsulation of saffron metabolites.

                      Saffron particles trapped in the maltodextrin support.                        Saffron particles and support are separated         

                      Preserves and optimizes safranal concentration                                No protection of saffron volatile metabolites

Compared to a classic atomization process in which saffron particles and support are separated, the Tech’care extraction^TM process allows saffron particles to be surrounded by the carrier matrix. Such process protects saffron volatile metabolites, especially safranal, and optimizes its concentration in the final extract. According to U-HPLC analysis, Safr’Inside™ is significantly richer in safranal than other saffron extracts: up to 10 times more than Spanish saffron extract.

     More on ACTIV’INSIDE

Activ’Inside, a French company specialized in saffron (Crocus sativus L.) and grapes (Vitis vinifera L.), aims to develop innovative natural products with high added value. “We use science, analysis, claims, intellectual property and marketing to create unique products reflecting customers’ need for a fast and safe access to market” says Benoit LEMAIRE, CEO of ACTIV’INSIDE.

At Activ’Inside, innovation and science are at the core of our activity, as demonstrated by our 3 patented active solutions based on sound scientific knowledge, proprietary published studies and related claims: Memophenol^TM, for cognitive health, SkinAx^TM, for the skin beauty, Safr’inside^TM, for mood / quality of sleep / premenstrual comfort.

Active solutions’s website : http://skinax.comI http://memophenol.comI http://safrinside.com

Activ’inside, a creator of difference for the Nutraceutical market, launch 4 new products and applications at VITAFOODS EUROPE 2019 (Geneva, May 7-9): a new crossover clinical study to enhance cognitive performance on students, an organic grape seed extract with a high OPC content, a tasteless & 100% soluble water grape seed extract, and some trendy fast ready-to-use formula.

Significant Results on Students Cognitive performance in only 90 Minutes

A new proprietary clinical study is now available on the patented ingredient Memophenol^TM. This randomized, double-blind crossover placebo controlled clinical study was conducted on students in one shot dosage. Cognitive performance was tested under exams conditions through validated cognitive tests.

Compared to a placebo,  a one shot Memophenol supplementation 90 minutes before exams is sufficient to  : 

• Significantly increase attention and working memory during at least one hour 
• Enhance cognitive performance by 36% 

Organic OPC from Grape Seed Extract

Thanks to a dedicated sourcing, Activ’Inside produces a grape seed extract guaranteed with a high polyphenols & OPC contents (60% Polyphenols and 25% OPC-Porter). Porter is the most accurate method to determinate the OPC content. Made in France,this extract is backed by a pending EFSA claim for its anti-aging benefits. This ingredient is available on private labelling formulations.

The Tasteless & 100% Water Soluble Grape Seed Extract

This 100% water Soluble & tasteless Grape seed extract provides a high amount of flavanol monomers proven by clinical trial for the best bioavailabilit yand antioxidant benefits. This extracts exclusively obtained from champagne grape varieties. 

Fast & Trendy Ready-to-use Formula

Activ’inside will present trendy and functional formulas like gummies to have a sensorial and enjoyable experience, liquid shots to boost the cognitive performance on students, instant drinks to offer great tasting product and attractive applications and functional chocolate swith effect on sleep, mood and memory.

More on ACTIV’INSIDE

Activ’Inside, a French company specialized in saffron (Crocus sativus L.) and grapes (Vitis vinifera L.), aims to develop innovative natural products with high added value. “We use science, analysis, claims, intellectual property and marketing to create unique products reflecting customers’ need for a fast and safe access to market” says Benoit LEMAIRE, CEO of ACTIV’INSIDE.

At Activ’Inside, innovation and science are at the core of our activity, as demonstrated by our 3 patented active solutions based on sound scientific knowledge, proprietary published studies and related claims: Memophenol^TM, for cognitive health, SkinAx^TM, for the skin beauty, Safr’inside^TM, for mood / quality of sleep / premenstrual comfort.

ACTIV’INSIDE, Science Inside, Claims Outside.

For more information: www.memophenol.com | www.skinAx.com | www.safrinside.com

Sponsor of the skipper Gildas BRETON for the 11e edition of “La Route du Rhum”

Beychac & Caillau, 2^nd October 2018: A sail, a boat and the ocean as far as the eye can see. This is what awaits the skipper Gildas Breton from November the 4^th when he will start the most difficult competition of his career: La Route du Rhum.

He won’t be alone in this great adventure. It’s notably in the colors of ACTIV’INSIDE that Gildas will take the race in Saint Malo, in Brittany, direction Point-à-Pitre, in Guadeloupe. How many participants this year? No fewer than 124 boats, a record, including 21 opponents Gildas will have to face in the RhumMulti category.

We’re counting on you Gildas! Follow us on twitter and Linkedin to keep informed on Gildas progress during the race.

More on Gildas Breton?

Aged of 55, Gildas is a real sea lover. Rocked by sailing since childhood, his record is growing year after year. Last reward: 2^nd place in real time at the Tour de Groix in 2017. For him, « La route du rhum » is a totally new challenge: “It’s a race that any sailor wants to do one day. This experience of crossing the Atlantic in solo is a real challenge, especially in terms of sleep, for me who have, so far, always took part of regatta between three buoys “says Gildas Breton to “La route du rhum” organizers (http://urlz.fr/7Rh8).

The skipper brilliantly completed the qualifications and is now in the phase of physical, mental and boat technical preparation. In order to protect his skin which will be under severe stress during its journey due to UV, wind, iodine and sea salt, Gildas Breton will take the active ingredient SkinAx^2TM, an antioxidant new-generation developed by Activ’Inside. SkinAx^2TM is a unique strong formula with a dual mechanism of action, combining both primary and secondary antioxidants, especially from grape monomers.

For more about Gildas Breton: www.forceocean.fr

More on “La route du Rhum” 

The “Route du Rhum” is a legendary French race taking place every 4 years. It will celebrate this year its 40 years. For this occasion, a beautiful gift: not less than 124 registered boats compared to only 38 the first year in 1978, and only 91 at the last edition in 2014. On the program, impressive numbers: about 6,560 km to go, 11 different nationalities, 124 boats of distinctive sizes divided into 6 categories, a starting line of more than 5 Km, for a solo crossing race of more than one week. The record is held by Loick Peyron, winner of the race in 2014, in 7 days, 15h, 8 minutes and 32 seconds.

More about « La route du rhum »: www.routedurhum.com

More on ACTIV’INSIDE: Maker of difference for the nutraceutical market

“What if your products contain more than just ingredients? A lot of science, a dose of analytical characterization, a measure of innovation, all with a quality, intellectual property and marketing coating, you let it go?”

Expert in saffron (crocus sativus L.) and grape (vitis vinifera L.) raw materials, the French biotech aims to develop innovative natural products with strong added values. “We use science, analytical, regulation, intellectual property and marketing to give UNIQUE PRODUCT, reflecting customer needs for a fast and safe access to market”.

ACTIV’INSIDE proposes ingredients for the nutraceutical market, from natural extract – mainly grape, saffron but also other – to patented active solution supported by a strong scientific background, proprietary published studies and relevant claims. 3 actives solutions dedicated to 3 majors application are available today: Cognition, Mood and Skin beauty. ACTIV’INSIDE private labelling with its ingredients.

ACTIV’INSIDE, Science Inside, Claims Outside.

For more information: www.memophenol.com | www.skinAx.com | www.safrinside.com

From Botanical EXTRACTS…

Through our expertise in grape and saffron, we propose ranges of botanical extracts.
We also develop tailor-made extracts according to your specifications.

• Signature saffron™ :

Range of extracts from Sargol saffron stigmas with the richest content in active metabolites including safranal, crocin and safromotivines.

• Signature grape™ :

Range of extracts from several grape parts providing different polyphenol profiles guaranteed according to both UV and U-HPLC analytical methods.

• Signature extract^TM :

Range of natural botanical extracts with guaranteed specifications, with the highest requirement in terms of quality and regulation.

… to dedicated APPLICATIONS

We aim to provide unique products with clear and differentiating messages.

Each are supported by:

• Proprietary studies: In-vitro, in-vivo, pilot, clinical and epidemiological
• Intellectual protection: Patents and trademarks
• Scientific publications: About proprietary studies, mechanisms or analysis methods
• Full analytical characterization: Both quantitative and qualitative
• Identifies mechanism of action: From proprietary and published data
• Relevant claims: EFSA claims, beauty claims and proprietary data

Discover our 3 innovative actives solutions

• : Cognitive Health. memophenol.com
• : Beauty from within. skinax.com
• : Mood, Pre-menstrual comfort, Sleep quality. safrinside.com

Activ’Inside also proposes private labeling with our active solutions, for a quicker and safer access to market.

Lear more about us: visit our dedicated websites including our totally new Memophenol^TM one. And follow us on Twitter and Linkedin.

ACTIV’INSIDE, Science Inside, Claims Outside.

For more information: www.memophenol.com | www.skinAx.com | www.safrinside.com

Finalist as “Botanical Product of the year”
of the Nutra Ingredients Awards Asia 2018

BORDEAUX (France), July 31^st, 2018 – ACTIV’INSIDE has been selected as finalist of the NutraIngredients Awards Asia 2018 with Safr’Inside^TM microtab, as the “Botanical product of the year”.

This original product assures quicker mood benefits, felt within 20 minutes only.

This award is associated with Vitafoods Asia 2018, which will take place at Singapore from 11 to 12 September 2018. ACTIV’INSIDE will be exhibitor at this show, booth N10 with is Asian Distributor Aqurate. Come to see us to discover our products.

Mood benefits felt within 20 minutes only.

Safr’Inside^TM microtab is a prototype of dietary supplement developed by Activ’Inside, in its private labelling offer.       This innovative product provides quick and effective effect on mood, in 20 minutes only, thanks to a sublingual administration and the highest content in safranal.

Contrary to classic dosage forms, Safr’Inside^TM microtab is presented in an original microtablet form. The sublingual administration of the microtablets induces a direct and quicker diffusion of saffron metabolites, including safranal, into the blood circulation, reaching rapidly the brain to positively act on mood regulators and neurotransmitters.

Each stick of 400 mg contains 30 mg of Safr’Inside^TM, the optimal dose demonstrated to have beneficial effect on mood. Safr’inside^TM is a patented extract of Iranian saffron stigmas whose chemical profile is backed by 10 clinical studies published on its mood benefits. Obtained from the reddest part of saffron stigmas (Sargol quality), Safr’Inside^TM provides the richest concentrations in safranal, crocin and safromotivines.

Safr’Inside^TM microtab is dedicated to people subjected to mood swings, afflicting more than 150 million people around the world (Qureshi et al. 2013). About 27% of Europeans, 47% of Americans, and 41% of Asians currently experience affective disorders, that can include nervousness, stress and anxiety. Safr’Inside^TM microtab has been developed to match with these consumer needs, as it represents an efficient science-backed natural mood stabilizer that provides quick benefits.

How does the awards selection works?

Safr’Inside^TM microtab has been selected from several others products. Each participant has submitted a file by May 2018.

“This award celebrates the best branded or own-label supplements, functional foods and beverages containing botanical and TCM (Traditional Chinese Medicine) ingredients”.

The selection was made according to 7 criteria:

• Brand recognition and the commercial success of your product, including evidence of strong retail and consumer interest or listings of your product.
• Consumer demand and interest in your format, delivery system, and/or matrix – including how innovative any delivery system is.
• Whether your product meets a consumer demand, and how relevant the botanical/TCM ingredient is in meeting this demand
• Packaging ease of use and design, including appeal and ease of use, novelty
• Evidence that the product works for its specified use, where possible this will be product specific research, however research citing the main active ingredients solely will also be considered.
• Evidence of that your product and its delivery system(s) has no, or beneficial, impact on bioavailability (especially if citing single ingredient data).
• What gives your product the ‘X factor’ – something that makes it stand out from the crowd and edge out the competition (including evidence to back up claims)

Once all entries had been received, they were reviewed by the NutraIngredients-ASIA Awards Judging Panel made up of independent judges from the industry.

The winner of the NutraIngredients Awards will be announced during awards ceremony on September 10^th, 2018 in Singapore.

More on ACTIV’INSIDE, your expert in Grape and Saffron applications

“What if your products contain more than just ingredients? A lot of science, a dose of analytical characterization, a measure of innovation, all with a quality, intellectual property and marketing coating, you let it go?”

Expert in saffron (crocus sativus L.) and grape (vitis vinifera L.) raw materials, the French biotech company ACTIV’INSIDE knows their compositions and applications more than anyone else. ACTIV’INSIDE proposes a large range of signature saffron and grape extracts, premium quality, including organic, vegan, kosher and halal ones. The company also valorises saffron and grape health benefits by developing proprietary natural active solutions, based on strong scientific background and clinically proven efficacy. 3 actives solutions dedicated to 3 majors application are available: Cognition, Mood and Skin beauty. Furthermore, if you want to be helped in the development of your finished products, ACTIV’INSIDE also proposes private labelling with its ingredients.

“ACTIV’INSIDE is your key partner in all your development projects. We use science, analytical, regulation, intellectual property and marketing to give you a UNIQUE PRODUCT, reflecting your customer needs for a fast and safe access to market” says Benoit LEMAIRE, CEO of ACTIV’INSIDE.

ACTIV’INSIDE, Science Inside, Claims Outside.

For more information: www.memophenol.com | www.skinAx.com | www.safrinside.com

A bi-centric, randomized, double-blind placebo-controlled clinical study confirms Memophenol™ effectiveness on seniors’ memory!

BORDEAUX (France), July 26, 2018 – ACTIV’INSIDE publishes a new study on Memophenol^TM, in the Journal of Gerontology. The clinical study performed on the product shows that the association of specific polyphenols from grape and blueberry improves episodic memory in healthy elderly.

Memophenol^TM clinical study

This study aimed to evaluate the effect of a 6-months dietary supplementation with a Polyphenols-Rich Extract from Grape and Blueberry (PEGB, trademark Memophenol^TM by Activ’Inside) on memory of healthy elderly subjects. The study involved 215 healthy seniors (Mini Mental State Examination score (MMSE) between 26 to 29) aged between 60-70 years old, orally supplemented with 300 mg twice a day of Memophenol^TM.

Learning, short and long-term memories were assessed using validated Neuropsychological tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Two tests were used before (T0) and after 6 months (T6) of supplementation:

• Verbal Recall Memory (VRM) test, assessing short-term memory: 18 words are shown one by one on a screen. People are then asked to recall as many words as possible, immediately (e. 1 min) following the presentation.
• The Paired Associated Learning (PAL) test, assessing long-term episodic memory. During this test, an increasing number of patterns have to be replaced, depending on the levels.

Figure 1: PAL score at baseline of the study population. N=190. Per protocol population.

The population was split into quartiles according to their corresponding baseline scores. Such approach allows selecting subjects according to their basal cognitive decline level.

To evaluate how Memophenol™ could correct a more pronounced memory loss, its effectiveness was evaluated on subjects with the worst PAL score at baseline (decliners) (figure 1).

– Memophenol^TM improves long-term episodic memory and learning

Figure 2: MemophenolTM efficacy on VRM-FR test.

After 6 months of supplementation, in the total population, the study shows that subjects supplemented with Memophenol^TM significantly improves their Verbal Free Recall Recognition Memory (VRM-FR, p=0.006) scores (figure 2).

Figure 3: Memophenol™ efficacy on PAL test assessed on decliners.

In addition, the subjects having the most important cognitive decline at baseline (t=0), also called “decliners”, significantly reduce the number of errors on the PAL test (p=0.037), thus highlighting episodic memory improvements.  This decrease is associated to 24% less errors versus placebo (figure 3).

Finally, the new publication shows that these cognitive improvements are interestingly associated with higher urinary concentration specific flavan-3-ols metabolites in the Memophenol^TM group, confirming that Memophenol^TM supplementation improves memory on seniors with a high bioavailability.

Memophenol^TM demonstrated efficacy

Thanks to this new study, Activ’Inside confirms the effectiveness of Memophenol™ on the age-related cognitive decline.

“This publication is a new piece of the Memophenol^TM puzzle. Indeed, fruit of a 4 year-international research program, Memophenol^TM is supported by not less than 10 publications and 1 patent.” says Benoit LEMAIRE, Chief Executive Officer at Activ’Inside.

Recently, ACTIV’INSIDE also published a new 12-year follow-up epidemiological study conducted with Inserm and Harvard, showing that polyphenols intake can prevent cognitive decline.

– What is Memophenol^TM?

Memophenol^TM is ACTIV’INSIDE innovative active formulation supported by science. Memophenol^TM results from a 4-year international research program initiated and led by ACTIV’INSIDE. This program of 4.2 million euros involved 10 academics and industrial partners, as well as 22 scientists, Ph. D. and engineers well recognized for their expertise in the fields of chemistry and biology of polyphenols, neuroscience and engineering of nutritional active ingredients.

The project started with data from epidemiological studies: polyphenols and specifically flavonoids are preventive effects on cognitive decline. Since that, several in-vitro and in-vivo tests has been performed on besides the large-scale clinical study. The mechanism of action has been identified: Memophenol^TM improves neurogenesis and synaptic plasticity, thanks to its unique profile in bioavailable polyphenols.

The effectiveness of Memophenol^TM has also been approved by students.

For more on Memophenol^TM: www.memophenol.com

More on ACTIV’INSIDE, your expert in Grape and Saffron applications

“What if your products contain more than just ingredients? A lot of science, a dose of analytical characterization, a measure of innovation, all with a quality, intellectual property and marketing coating, you let it go?”

Expert in saffron (crocus sativus L.) and grape (vitis vinifera L.) raw materials, the French biotech company ACTIV’INSIDE knows their compositions and applications more than anyone else. ACTIV’INSIDE proposes a large range of signature saffron and grape extracts, premium quality, including organic, vegan, kosher and halal ones. The company also valorises saffron and grape health benefits by developing proprietary natural active solutions, based on strong scientific background and clinically proven efficacy. 3 actives solutions dedicated to 3 majors application are available: Cognition, Mood and Skin beauty. Furthermore, if you want to be helped in the development of your finished products, ACTIV’INSIDE also proposes private labelling with its ingredients.

“ACTIV’INSIDE is your key partner in all your development projects. We use science, analytical, regulation, intellectual property and marketing to give you a UNIQUE PRODUCT, reflecting your customer needs for a fast and safe access to market” says Benoit LEMAIRE, CEO of ACTIV’INSIDE.

ACTIV’INSIDE, Science Inside, Claims Outside.