SAFR’INSIDE™

Safr’Inside™ supports menopausal health by modulating the pathway of the happiness neurotrasmitter (serotonin), which is disrupted by estrogen loss. An ex vivo study conducted by Activ’Inside demonstrates that metabolites of Safr’Inside™ digestion:

– Enhance serotonin release: Restores serotonin levels under stress, supporting emotional balance.
– Reduction in serotonin reuptake: Decreases SERT expression, increasing serotonin receptor activation.
– Limit serotonin degradation: Reduces 5-HIAA production, preserving serotonin levels.

These effects help address menopausal symptoms, including emotional dysregulation, hot flashes, and night sweats, by improving serotonin activity and balance.


Vitamin B6

Vitamin B6 plays a crucial role in neurotransmitter synthesis, acting as a rate-limiting cofactor for the production of serotonin, dopamine, GABA, noradrenaline, and melatonin. Even mild vitamin B6 deficiency preferentially reduces GABA and serotonin synthesis, which:

– Reduces GABA levels: Leading to decreased cortisol inhibition and contributing to mood and sleep disturbances.
– Increases cortisol levels: Resulting in heightened stress and disrupted sleep.

By increasing vitamin B6 intake, cortisol levels may decrease, improving mood and sleep quality, thereby alleviating menopausal symptoms associated with neurotransmitter dysregulation.

SAFR’INSIDE™

Safr’Inside™ is an effective non-hormonal supplementation for menopause, significantly improving both physical symptoms (hot flashes) and psychological symptoms (emotional balance) within as little as two weeks.

Hot Flashes and Emotional Symptoms:
– A clinical study on 60 postmenopausal women showed that 6 weeks of saffron stigma extract supplementation (30 mg/day) significantly reduced menopause symptoms, compared to placebo.
– Complete response rates and remission rates were significantly higher in the saffron group at 4 and 6 weeks, demonstrating both physical and psychological improvements.

Emotional Balance:
– In a double-blind, randomized trial, 56 healthy subjects with feelings of sadness or anxiety received Safr’Inside™ (30 mg/day) for 56 days.
Results showed significant improvements in emotional state and social relationships, compared to placebo. These improvements correlated with the bioavailability of saffron metabolites, as proven by increased urinary crocetin levels from day 14.

Vitamin B6

Vitamin B6 plays a vital role in regulating hormonal activity, as established by European authorities. It supports the action of key hormones, including androgens, estrogens, progesterone, and thyroid hormones. The proven cause-and-effect relationship between vitamin B6 intake and hormonal regulation highlights its potential in alleviating menopausal symptoms linked to hormonal imbalances. This includes mood disorders, sleep disturbances, and physical symptoms commonly experienced during menopause.