Stress Management
The only encapsulated saffron extract
Sargol quality (Crocus sativus L.)
100% Persian saffron
European sourcing available
Proprietary U-HPLC method
More than 25 compounds identified and characterized by our proprietary published U-HPLC method.
Innovative extraction process
Safr'Inside™
-
Tech'Care Extraction™The only encapsulated saffron extract obtained with a patented soft extraction process allowing to:
- Preserve the native composition of saffron
- Retain volatile compounds, such as safranal, usually lost during extraction
- Protect from alterations
-
Richest extract in safranal
- Safranal is the most described saffron compound for its action on serotonin amplification.
- 10 times more safranal in Safr'Inside™ than in non-encapsulated saffron extracts.
- Analysis by U-HPLC.
Efficiency confirmed by Science
Safr'Inside™
-
Fluoxetine-like effectSaffron efficacy has been also shown to be statistically similar to Fluoxetine and Imipramine, the main pharmaceutical drugs used to treat anxiety & depressive syndromes. These benefits are obtained without any side effect.
-
Proprietary clinical study on healthy peopleRandomized double-blind placebo controlled :
- 56 healthy adults
- 18-60 years
- Non-pathological feelings of depression
- Chronic supplementation (8 weeks): 15 mg twice /day
- Acute dosage : 30 mg
- Safr'Inside™ has a direct action on stress which results in an improvement of the relationships.
- Safr'Inside™ is bioavailable.
- There is a correlation between this bioavailability and the improvement of psychological parameters.
- Efficient within 30 min
- Safr'Inside™ lowers stress physical impact on heart.
Physiological effects of Safr'Inside™ on stress
Safr'inside™
Serotonin booster
Balances brain neurotransmitters involved in emotional state.
66% serotonin inhibition (SSRI)
Neuroprotection
Protects neurons against stress induced toxicity
significant ROS inhibition
Activation of the relaxing nervous system
Maintains homeostasis of the heart rate variability during stressful situation.
within 30 min
Modulation of the gut-brain axis
.
Decreases anxiety by restoring a healthy microbiota, notably by boosting Akkermansia
prebiotic effect
Modulation of cortisol secretion
Safr'Inside™ and the safranal it contains modulates the biological response to stress.
acute effect in less than 30 min
Clinical results
Reduction of inflammation
.
Limits inflammation in gut and joint cells, showing a global anti-inflammatory effect
Anti-inflammatory properties
Clinical ex-vivo results
How to use Safr'Inside™ in your food supplement ?
Anti-Stress & Sleep
Woman Health
Well being nutrition
Claims
EFSA pending claims :
"Contributes to emotional balance."
"Helps to maintain good comfort before and during menstrual cycle."
"Helps to find a better sleep."
"Contributes to relieve menopause symptoms."
US Structure/Function claims (validated by Venable) :
"Safr´Inside™ helps with stress management in daily life"
"Safr’Inside™ supports a normal, healthy attitude during PMS"
"Helps to promote a feel of calm or serenity"
Need more claims ?
"Contributes to emotional balance."
"Helps to maintain good comfort before and during menstrual cycle."
"Helps to find a better sleep."
"Contributes to relieve menopause symptoms."
US Structure/Function claims (validated by Venable) :
"Safr´Inside™ helps with stress management in daily life"
"Safr’Inside™ supports a normal, healthy attitude during PMS"
"Helps to promote a feel of calm or serenity"
Need more claims ?
Dose & galenic form
30 mg/day
Beneficial effects
confirmed by consumers
Safr'Inside™
*Consumer test on 50 healthy adults, 30 mg/day during 30 days.
-
After only 15 days
of consumers are more optimistic*
People feel their emotional balance had improved*
Consumers are satisfied by the effectiveness* of Safr'Inside™
-
After 30 days
Consumers felt improvements* in Sleep quality
Réf.
Our product
Health benefits
Qualities
Characteristics
PR-0033
Safr'inside™
Premenstrual Syndrome
Menopause
Sport Vitality
Digestive Health
Joint
Sleep
Mood & Anti-Stress
Traditional dry extract of saffron. Iranian sargol quality with appellation of origin
PR-0153
Safr'inside™ CO
Premenstrual Syndrome
Menopause
Sport Vitality
Digestive Health
Joint
Sleep
Mood & Anti-Stress
European dry extract of saffron with protected appellation of origin
Sleep
The only encapsulated saffron extract
Sargol quality (Crocus sativus L.)
100% Persian saffron
European sourcing available
Proprietary U-HPLC method
More than 25 compounds identified and characterized by our proprietary published U-HPLC method.
Innovative extraction process
Safr'Inside™
-
Tech'Care Extraction™The only encapsulated saffron extract obtained with a patented soft extraction process allowing to:
- Preserve the native composition of saffron
- Retain volatile compounds, such as safranal, usually lost during extraction
- Protect from alterations
-
Richest extract in safranal
- Safranal is the most described saffron compound for its action on serotonin amplification.
- 10 times more safranal in Safr'Inside™ than in non-encapsulated saffron extracts.
- Analysis by U-HPLC.
Clinically Proven Efficacy
2 double blind & placebo controlled studies
Study 1 :
Randomized double-blind placebo controlled :
- 52 subjects
- ≥ 55 y.o.
- Sleep complaints
- 30 mg of Safr’Inside™ - Gummy form
- 30 minutes before bed
- Objective and Subjective measurements
Results on subjective sleep
-
A - PSQI (global score)Safr’Inside™ significantly improves sleep quality after 28 days, as evidenced by a 21.3% reduction in PSQI score.
-
B - PSQI (global score) change from baselineSafr’Inside™ induces a significant change in PSQI compared to placebo, highlighting its benefits on sleep quality.
Results on objective sleep
-
Safr’Inside™ significantly reduces Sleep Onset LatencySafr’Inside™ significantly reduces Sleep Onset Latency by 35.4% compared to placebo, promoting sleep onset.
-
Safr’Inside™ significantly reduces Latency to persistent SleepSafr’Inside™ significantly reduces Latency to persistent Sleep by 35.9% compared to placebo, promoting persistent sleep.
-
Safr’Inside™ significantly reduces Wake durationSafr’Inside™ significantly reduces Wake duration by 43.2% compared to placebo, promoting restful sleep.
Results on gut microbiome modulation
-
Safr’Inside™ significantly modulates the gut-sleep-brain axisSafr’Inside™ modulates the microbiome compared to placebo, as evidenced by the change in relative bacteria abundance. This modulation was correlated with the improvement of sleep quality, highlighting the ability of Safr’Inside™ to act on the gut-sleep-brain axis.
Study 2 :
Randomized double-blind placebo-controlled clinical trial:
- 158 subjects
- 18y.o ≤ age ≤ 65y.o
- Moderate insomnia
- 20/30 mg of Safr’Inside™ per day - Capsule form
- 60 minutes before bed
Results on subjective sleep
-
Safr’Inside™ significantly increases SQS scoreSafr’Inside™ induces a significant increase in sleep quality compared to placebo after just 21 days. Safr’Inside™ significantly improves SQS score at both 20mg (+24.3%) and 30mg (+27.2%). Safr’Inside™ significantly improves subjective sleep quality compared to placebo. These benefits are perceived after only 21 days of supplementation from 20mg of Safr’Inside™ daily.
How to use Safr'Inside™ in your food supplement ?
Anti-Stress & Sleep
Woman Health
Well being nutrition
Claims
EFSA pending claims :
"Contributes to emotional balance."
"Helps to maintain good comfort before and during menstrual cycle."
"Helps to find a better sleep."
"Contributes to relieve menopause symptoms."
US Structure/Function claims (validated by Venable) :
"Safr´Inside™ helps with stress management in daily life"
"Safr’Inside™ supports a normal, healthy attitude during PMS"
"Helps to promote a feel of calm or serenity"
Need more claims ?
"Contributes to emotional balance."
"Helps to maintain good comfort before and during menstrual cycle."
"Helps to find a better sleep."
"Contributes to relieve menopause symptoms."
US Structure/Function claims (validated by Venable) :
"Safr´Inside™ helps with stress management in daily life"
"Safr’Inside™ supports a normal, healthy attitude during PMS"
"Helps to promote a feel of calm or serenity"
Need more claims ?
Dose & galenic form
30 mg/day
Réf.
Our product
Health benefits
Qualities
Characteristics
PR-0033
Safr'inside™
Premenstrual Syndrome
Menopause
Sport Vitality
Digestive Health
Joint
Sleep
Mood & Anti-Stress
Traditional dry extract of saffron. Iranian sargol quality with appellation of origin
PR-0153
Safr'inside™ CO
Premenstrual Syndrome
Menopause
Sport Vitality
Digestive Health
Joint
Sleep
Mood & Anti-Stress
European dry extract of saffron with protected appellation of origin
Menopause
The only encapsulated saffron extract
Sargol quality (Crocus sativus L.)
100% Persian saffron
European sourcing available
Proprietary U-HPLC method
More than 25 compounds identified and characterized by our proprietary published U-HPLC method.
Innovative extraction process
Safr'Inside™
-
Tech'Care Extraction™The only encapsulated saffron extract obtained with a patented soft extraction process allowing to:
- Preserve the native composition of saffron
- Retain volatile compounds, such as safranal, usually lost during extraction
- Protect from alterations
-
Richest extract in safranal
- Safranal is the most described saffron compound for its action on serotonin amplification.
- 10 times more safranal in Safr'Inside™ than in non-encapsulated saffron extracts.
- Analysis by U-HPLC.
Clinically Proven Efficacy
Randomized double-blind placebo-controlled clinical study:
- 104 Healthy women
- >40y.o
- Typical perimenopausal symptoms
- Presenting a total GCS score ≥20
- 30 mg Safr’Inside™
-
Total perimenopausal symptomsSafr’Inside™ significantly reduces perimenopausal symptoms (total GCS score) from week 6 (-44%).
-
Night sweatsSafr’Inside™ significantly reduces night sweats (GCS item score) from week 6 (-41%).
-
Total mood disturbanceSafr’Inside™ significantly reduces total mood disturbance (total POMS score) from week 6 (-21%).
-
Vitality/ EnergySafr’Inside™ significantly improves vitality & energy (SF-36 vitality scale) from week 6 (+59%).
How to use Safr'Inside™ in your food supplement ?
Anti-Stress & Sleep
Woman Health
Well being nutrition
Claims
EFSA pending claims :
"Contributes to emotional balance."
"Helps to maintain good comfort before and during menstrual cycle."
"Helps to find a better sleep."
"Contributes to relieve menopause symptoms."
US Structure/Function claims (validated by Venable) :
"Safr´Inside™ helps with stress management in daily life"
"Safr’Inside™ supports a normal, healthy attitude during PMS"
"Helps to promote a feel of calm or serenity"
Need more claims ?
"Contributes to emotional balance."
"Helps to maintain good comfort before and during menstrual cycle."
"Helps to find a better sleep."
"Contributes to relieve menopause symptoms."
US Structure/Function claims (validated by Venable) :
"Safr´Inside™ helps with stress management in daily life"
"Safr’Inside™ supports a normal, healthy attitude during PMS"
"Helps to promote a feel of calm or serenity"
Need more claims ?
Dose & galenic form
30 mg/day
Participant Satisfaction
Safr'Inside™
*104 healthy women >40 y.o, 30 mg/day over 12 weeks.
Safr’Inside™ was highly appreciated by participants
Réf.
Our product
Health benefits
Qualities
Characteristics
PR-0033
Safr'inside™
Premenstrual Syndrome
Menopause
Sport Vitality
Digestive Health
Joint
Sleep
Mood & Anti-Stress
Traditional dry extract of saffron. Iranian sargol quality with appellation of origin
PR-0153
Safr'inside™ CO
Premenstrual Syndrome
Menopause
Sport Vitality
Digestive Health
Joint
Sleep
Mood & Anti-Stress
European dry extract of saffron with protected appellation of origin
