Crocus sativus L.
  • Active ingredient

Choose an efficient saffron extract that associates proprietary science and premium botanical with neuronutrition & women health claims.
Our patented ingredient, Safr’Inside™, is the only encapsulated saffron extract preserving the full spectrum of saffron with the highest concentration of safranal (O,2% U-HPLC) for a complete action on stress.

Mood & Anti-Stress
Digestive Health
Premenstrual Syndrome
Sport Vitality


saffron metabolites
The only encapsulated saffron extract
Sargol quality (Crocus sativus L.)
100% Persian saffron
European sourcing available
Proprietary U-HPLC method
More than 25 compounds identified and characterized by our proprietary published U-HPLC method.
Innovative extraction process
  • Tech'Care Extraction™
    The only encapsulated saffron extract obtained with a patented soft extraction process allowing to:

    • Preserve the native composition of saffron
    • Retain volatile compounds, such as safranal, usually lost during extraction
    • Protect from alterations

    full spectrum saffron extract
  • Richest extract in safranal

    • Safranal is the most described saffron compound for its action on serotonin amplification.
    • 10 times more safranal in Safr'Inside™ than in non-encapsulated saffron extracts.
    • Analysis by U-HPLC.

    safranal analysis

Scientifically proven efficiency

Efficiency confirmed by Science
  • Fluoxetine-like effect
    Saffron efficacy has been also shown to be statistically similar to Fluoxetine and Imipramine, the main pharmaceutical drugs used to treat anxiety & depressive syndromes. These benefits are obtained without any side effect.
    saffron fluoxetine like effect
  • Proprietary clinical study on healthy people
    Randomized double-blind placebo controlled :

    • 56 healthy adults
    • 18-60 years
    • Non-pathological feelings of depression
    • Chronic supplementation (8 weeks): 15 mg twice /day
    • Acute dosage : 30 mg

    Chronic supplementation :

    • Safr’Insidehas a direct action on stress which results in an improvement of the relationships.
    • Safr'Inside™ is bioavailable.
    • There is a correlation between this bioavailability and the improvement of psychological parameters.

    Acute dosage :

    • Efficient within 30 min
    • Safr'Inside™ lowers stress physical impact on heart.

    Proprietary clinical study (Jakson et al, 2020)

    saffron improves mood and social relationships
Physiological effects of Safr'Inside™ on stress
Serotonin booster

Balances brain neurotransmitters involved in emotional state.

66% serotonin inhibition (SSRI)

safranal serotonine amplification

Protects neurons against stress induced toxicity

significant ROS inhibition

stress saffron neuroprotection
Activation of the relaxing nervous system

Maintains homeostasis of the heart rate variability during stressful situation.

within 30 min

saffron anti stress balance parasympathetic
Modulation of the gut-brain axis

Decreases anxiety by restoring a healthy microbiota, notably by boosting Akkermansia

prebiotic effect

gut brain axis saffron akkermansia
Modulation of cortisol secretion

Safr'Inside™ and the safranal it contains modulates the biological response to stress.

acute effect in less than 30 min

Clinical results

Reduction of inflammation

Limits inflammation in gut and joint cells, showing a global anti-inflammatory effect

Anti-inflammatory properties

Clinical ex-vivo results

Claims Doses & Galenics

How to use Safr'Inside™ in your food supplement ?
saffron extract for nutraceutical product
Anti-Stress & Sleep
sleep nutraceutical ingredients
Women Health
PMS nutraceutical ingredients
women sexual health nutraceutical ingredients
Well Being nutrition
digestive health nutraceutical ingredients

EFSA pending claims :
"Contributes to emotional balance."
"Helps to maintain good comfort before and during menstrual cycle."
"Helps to find a better sleep."
"Contributes to relieve menopause symptoms."

US Structure/Function claims (validated by Venable) :
"Safr´Inside™ helps with stress management in daily life"
"Safr’Inside™ supports a normal, healthy attitude during PMS"
"Helps to promote a feel of calm or serenity"
Need more claims

Dose &
galenic form

30 mg/day

Consumer reviews

Beneficial effects
confirmed by consumers

*Consumer test on 50 healthy adults, 30 mg/day during 30 days.

  • After only 15 days
4/5 results consumer study safrinside
Consumers are satisfied by the effectiveness* of Safr'Inside™
  • After 30 days
1/2 results consumer study safrinside
Consumers felt improvements* in Sleep quality

Our products
Our product
Health benefits
Premenstrual Syndrome
Sport Vitality
Digestive Health
Mood & Anti-Stress

Traditional dry extract of saffron. Iranian sargol quality with appellation of origin

Safr'inside™ CO
Premenstrual Syndrome
Sport Vitality
Digestive Health
Mood & Anti-Stress

European dry extract of saffron with protected appellation of origin

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